Embedded Files
Figures from Johnson et al, Brain Comm, 2023 / Johnson et al, Molec Psychiatry, 2024 / Johnson et al, Biol Psychiatry: Cogn Neurosci Neuroimaging, 2020 / Johnson et al, Brain, 2020 / Johnson et al, J Neurol Neurosurg Psychiatry, 2019.
MDS_2020_TS_DBS_Tract_Activation.pdfSeptember 2020
International Congress of Parkinson's Disease & Movement DisordersVirtualSFN_2019_TS_DBS_Connectivity_print.pdfOctober 2019
Society for Neuroscience (SfN)Chicago, ILMDS_2019_TS_DBS_Connectivity_print.pdfSeptember 2019
International Congress of Parkinson's Disease & Movement DisordersNice, FranceMDS_2018_TS_DBS_Imaging.pdfSeptember 2018
International Congress of Parkinson's Disease & Movement DisordersHong KongOHBM_SCC_DBS_Poster_Final.pdfJune 2017
Organization for Human Brain Mapping (OHBM)Vancouver, BC, Canada
de Hemptinne Lab -- 2020-Present
de Hemptinne Lab -- 2020-Present
Departments of Neurology and Neurosurgery, Norman Fixel Institute for Neurological Diseases, University of Florida
Role: Postdoctoral Associate
Research Support:
Norman Fixel Institute Pilot Awards -- 2023-2025
NIH NINDS K99/R00 Pathway to Independence Award [NS137249] -- 2025-2030
Projects:
Evoked resonant neural activity (ERNA) to guide deep brain stimulation (DBS) for movement disorders: My research aimed to study the evoked resonant neural activity (ERNA) as a novel marker to guide DBS targeting and postoperative programming to improve DBS for Parkinson's disease. Our results showed pallidal ERNA is spatially localized to specific pallidal subregions and is a promising predictor for therapeutic stimulation contact (Johnson et al, Brain Comm, 2023). Additionally, we have been exploring the use of ERNA to guide DBS for dystonia (Johnson et al, Brain Stimulation, 2024).
Neurophysiological markers of psychiatric symptoms in Parkinson's disease: My K99/R00 award aims to identify novel neurophysiological markers of depression in Parkinson's disease using intraoperative and chronic neural recordings, neuroimaging, computational modeling, and AI. Our initial results suggest elevated pallidal beta power (13-30 Hz) may be associated with depression in Parkinson's disease, thus suggesting that beta power may be involved in Parkinson's disease pathophysiology beyond only motor symptoms (Johnson et al, in review, preprint DOI: 10.21203/rs.3.rs-5952073/v1).
Select Publications:
Johnson KA, Sarmento FP, Wong JK, Hilliard JD, Foote KD, de Hemptinne C, “Evoked Resonant Neural Activity in the Pallidal-Subthalamic Circuit During Dual Lead Deep Brain Stimulation in DYT-TOR1A Dystonia: A Case Study”, Brain Stimulation, 2024. DOI: 10.1016/j.brs.2024.11.001.
Coutinho PB, Johnson KA, Seritan AL, Galifianakis NB, Coleman R, Wang D, Racine CA, Ostrem JL, Starr PA, de Hemptinne C, “Elevated Mood Induced by Subthalamic Nucleus Deep Brain Stimulation: A Video-Recorded Case Report”, Tremor and Other Hyperkinetic Movements, 2024. DOI: 10.5334/tohm.900.
Johnson KA, Okun MS, Scangos KW, Mayberg HS, de Hemptinne C, “Deep Brain Stimulation for Refractory Major Depressive Disorder: A Comprehensive Review” , Mol Psychiatry, 2024. DOI: 10.1038/s41380-023-02394-4.
Johnson KA, Cagle JN, Lopes JL, Wong JK, Okun MS, Gunduz A, Shukla AW, Hilliard JD, Foote KD, de Hemptinne C, “Globus pallidus internus deep brain stimulation evokes resonant neural activity in Parkinson’s disease”, Brain Communications, 2023. DOI: 10.1093/braincomms/fcad025.
Johnson KA, Worbe Y, Foote KD, Butson CR, Gunduz A, Okun MS, “Tourette Syndrome: Clinical Features, Pathophysiology, and Treatment”, Lancet Neurology, 2022. DOI: 10.1016/S1474-4422(22)00303-9.
Butson Lab -- 2016-2020
Butson Lab -- 2016-2020
Lab Website -- Department of Biomedical Engineering, Scientific Computing & Imaging (SCI) Institute, University of Utah
Role: PhD student / NSF Graduate Research Fellow
Research Support:
National Science Foundation (NSF) Graduate Research Fellowship Program (GRFP) [1747505] -- 2018-2021
Scientific Computing & Imaging Institute Graduate Fellowship in Computational Systems Bioengineering -- 2016-2020
Projects:
Deep Brain Stimulation (DBS) for Tourette Syndrome (TS): I collaborated with the International TS DBS Registry and Database, a multisite consortium of TS DBS researchers and clinicians, to curate a novel dataset comprised of neuroimaging, stimulation settings, and clinical outcomes for over 130 TS DBS patients. My goal was to identify predictors of symptom improvement, including the site of stimulation (Johnson et al, JNNP, 2019), the modulated structural networks (Johnson et al, Brain, 2020), and the modulated basal ganglia fiber pathways (Johnson et al, Biol Psychiatry: CNNI, 2020) using neuroimaging and computational models of DBS.
Deep Brain Stimulation (DBS) for Depression: I generated computational models of the volume of tissue activated by DBS for patients who underwent DBS of the subcallosal cingulate cortex as part of a randomized clinical trial at the University of Calgary (Dr. Zelma Kiss, Dr. Rajamannar Ramasubbu). The goal of the project was to quantify fiber tract activation associated with improvement in depressive symptoms (Clark et al, 2020a).
Select Publications:
Johnson KA, Duffley G, Foltynie T et al, Basal Ganglia Pathways Associated with Therapeutic Pallidal Deep Brain Stimulation for Tourette Syndrome, Biol Psychiatry: Cogn Neurosci Neuroimaging, 2020, DOI: 10.1016/j.bpsc.2020.11.005.
Johnson KA, Duffley G, Anderson DN et al, Structural Connectivity Predicts Clinical Outcomes of Deep Brain Stimulation for Tourette Syndrome, Brain, 2020, DOI: 10.1093/brain/awaa188.
Clark DL, Johnson KA, Butson CR, Lebel C, Gobbi D, Ramasubbu R, Kiss ZHT, Tract-based analysis of target engagement by subcallosal cingulate deep brain stimulation for treatment resistant depression, Brain Stimulation, 2020, vol. 13, iss. 4, pp. 1094-1101, DOI: 10.1016/j.brs.2020.03.006.
Johnson KA, Fletcher PT, Servello D, et al, Image-Based Analysis and Long-Term Clinical Outcomes of Deep Brain Stimulation for Tourette Syndrome: A Multisite Study, J Neurol Neurosurg Psychiatry, 2019, vol. 90, iss. 10, pp. 1078-1090, DOI: 10.1136/jnnp-2019-320379.
Comprehensive Arrhythmia Research and Management Center -- 2013-2016
Comprehensive Arrhythmia Research and Management Center -- 2013-2016
Division of Cardiovascular Medicine, University of Utah
Role: Part-time image processing research technician.
Projects:
Performed segmentation of cardiac MR images for clinical procedures and research projects related to cardiac arrhythmias. Contributed to several clinical research projects using cardiac MRI to study the role of tissue remodeling in cardiac arrhythmias (Chelu et al 2018).
Developed a method for calculating conduction velocity in cardiac tissue using intraoperative electrophysiological recordings (undergraduate thesis project).
Research Support:
University of Utah Undergraduate Research Opportunities Program (UROP) -- 2013-2014
Select Publications:
Chelu MG, King JB, Kholmovski EG, Ma J, Gal P, Marashly Q, AlJuaid MA, Kaur G, Silver MA, Johnson KA, Suksaranjit P, Wilson BD, Han FT, Elvan A, Marrouche NF, Atrial fibrosis by LGE-MRI and catheter ablation of atrial fibrillation: five years follow up data, J Am Heart Assoc, 2018, vol. 7, pp. e006313, DOI: 10.1161/JAHA.117.006313.
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